Anti-Inflammatory Activity of Oxycarotenoid
Extracts Isolated from Coriander Leaves
(Coriandrum Sativum) and Curry Leaves
(Murraya koenigii) on Carrageenan Induced
Acute Inflammation in Rats
Published: January 1, 2021 | DOI: https://doi.org/10.7860/JCDR/2021/46322.14446
AM ANUSHA, PA SHERENA, PT ANNAMALA, JK Mukkadan
1. Professor, Department of Pathology, PK Das Institute of Medical Sciences, Ottapalam, Palakkad, Kerala, India.
2. Scientist, Department of Biochemistry, Little Flower Medical Research Centre, Angamaly, Ernakulam, Kerala, India.
3. Professor and Head, Department of Biochemistry, Jubilee Mission Medical College and Research Institute, Trichur, Kerala, India.
4. Director, Little Flower Medical Research Centre, Angamaly, Ernakulam, Kerala.
Correspondence
PT Annamala,
Professor and Head, Department of Biochemistry, Jubilee Mission Medical College
and Research Institute, Trichur, Kerala, India.
E-mail: drannamala@gmail.com
Introduction: Green leafy vegetables are important sources of polyphenols and carotenoids which possess both antioxidant and anti-inflammatory activities.
Aim: To study the anti-inflammatory activity of oxycarotenoid extracts isolated from coriander leaves (Coriandrumsativum) and curry leaves (Murraya koenigii) in carrageenan induced acute paw oedema in rats.
Materials and Methods: Oxycarotenoid extracts were isolated from the coriander leaves (Coriandrum sativum) and curry leaves (Murraya koenigii) and they were assessed for antiinflammatory activities by in-vivo methods. The in-vivo antiinflammatory activity was evaluated in carrageenan induced acute paw oedema model. Indomethacin at a dose of 20 mg/Kg body weight was used as standard anti-inflammatory drug.
Results: The results revealed that oxycarotenoids extracted from coriander leaves administered at a dose of 40 mg/ kg body weight showed an inhibition of 53.33% whereas the oxycarotenoids extracted from curry leaves showed an inhibition of 60% at the sixth hour after carrageenan injection. The results are comparable with those of indomethacin (20 mg/ Kg body weight) administered group which showed an inhibition of 55.53%
Conclusion: These findings suggest that oxycarotenoid extracts isolated from leafy vegetables (coriander leaves and curry leaves) have significant anti-inflammatory activities.
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